Priscilla Van Wynsberghe

BA, Ohio Wesleyan University, 2001; PhD, University of Wisconsin-Madison, 2007

• Howard Hughes Medical Institute Teaching Fellow, University of Wisconsin-Madison 2005-2006;
• Teaching Assistant, University of Wisconsin-Madison 2002-2003

Microbiology, Genetics, Molecular Biology, RNA biology, Women's Biology

Understanding how small RNAs called microRNAs, and the proteins that control microRNAs regulate somatic and germ line development in the nematode C. elegans.

Understanding how exposure to a chemical in one generation can impact gene expression in subsequent generations.

• *Berardi, S., A. McFall*, A. Toledo-Hernandez*, C. Coote*, H. Graham*, L. Stine*, K. Rhodehouse*, A. Auernhamer* and P. M. Van Wynsberghe². 2018 The Period protein LIN-42 regulates germline development in C. elegans. Mechanism of Development. 153:42-53.
• *Rhodehouse, K., K. Cascino*, L. Aseltine*, A. Padula*, R. Weinstein*, J. Spina*, C. Olivero*, and P. M. Van Wynsberghe². 2018. The doubletime homolog KIN-20 mainly regulates let-7 independently of its effects on the Period homolog LIN-42 in Caenorhabditis elegans. G3: Genes, Genomes and Genetics. 8:2617-2729.
• ²Van Wynsberghe, P. M. and A.E. Pasquinelli. 2014. Period homolog LIN-42 regulates miRNA transcription to impact developmental timing. Worm. 3:e974453.
• ²Van Wynsberghe, P. M., E.F., Finnegan, T. Stark, E.P. Angelus*, K.E. Homan*, G.W. Yeo, and A.E. Pasquinelli². 2014. The period protein homolog LIN-42 negatively regulates microRNA biogenesis in C. elegans. Dev. Biol. 390:126-35.
• Gimenez-Barcons, M., I. Alves-Rodrigues, J. Jungfleisch, P.M. Van Wynsberghe, P. Ahlquist, and J. Diez. 2013. The cellular decapping activators Lsm1, Pat1, and Dhh1 control the ratio of subgenomic to genomic flock house virus RNAs. J. Virol. 87:6192-200.
• Van Wynsberghe, P. M., and E. M. Maine. 2013. Epigenetic control of germline development. In “Advances in Experimental Medicine and Biology - Germ Cell Development in C. elegans” (T. Schedl, Ed.), Springer Science, New York. 757:373-403.
• ¹Van Wynsberghe, P. M., ¹S. P. Chan, F. J. Slack, and A. E. Pasquinelli. 2011. Analysis of microRNA expression and function. In “Methods in Cell Biology – Caenorhabditis elegans” (J. H. Rothman, Ed.), Elsevier Inc., San Diego. 106:219-52.
• Van Wynsberghe, P. M., Z. S. Kai, K. B. Massirer, V. H. Burton, G. W. Yeo, and A. E. Pasquinelli. 2011. LIN-28 co-transcriptionally binds primary let-7 to regulate miRNA maturation in Caenorhabditis elegans. Nat. Struct. Mol. Biol. 18:302-8.
• ¹Bracht, J. R., ¹P. M. Van Wynsberghe, V. Mondol, and A. E. Pasquinelli. 2010. Regulation of lin-4 miRNA expression, organismal growth and development by a conserved RNA binding protein in C. elegans. Dev. Biol. 348:210-21.
• Van Wynsberghe, P. M. and P. Ahlquist. 2009. 5’ cis-elements direct nodavirus RNA1 recruitment to mitochondrial sites of replication complex formation. J. Virol. 83:2976-88.
•  Van Wynsberghe, P. M., H. R. Chen, and P. Ahlquist. 2007. Nodavirus RNA replication protein A induces membrane association of genomic RNA. J. Virol. 81:4633-44.

¹ co-first authors
² corresponding author
* Colgate University Undergraduate

Postdoctoral Fellow, University of California at San Diego, 2007-2010; Postdoctoral Fellow, Syracuse University, 2010-2011

• NIH NRSA Postdoctoral Fellowship 2009-2011
• HHMI Teaching Fellow 2005-2006
• HHMI Predoctoral Fellowship 2001-2006
• Phi Beta Kappa 2001
• Sigma Xi Student Research Award 2001