Deb Kreiss - Psychology Faculty - Colgate University

Colgate Directory




FACULTY DETAIL    < BACK TO RESULTS
Deb Kreiss

Deb Kreiss

Visiting Assistant Professor of Psychology and Neurosciences
Psychology, 105E Olin Hall
p 315-228-6116

Degrees

  • PhD from University of Pennsylvania. Neuroscience
  • BA from Cornell University. Double major: Chemistry and Biology & Society

Specialties

Behavioral neuroscience, psychopharmacology, neurophysiology, biological basis of psychiatric disorders

Research Interests

My research concerns the evaluation of two potential animal models of Obsessive Compulsive Disorder (OCD). OCD is an anxiety disorder that results in unwanted, repetitive thoughts (i.e. obsessions) which are followed by overwhelming urges to perform ritualistic behaviors (i.e. compulsions). Although OCD affects 2 - 3% of the world’s population, relatively little is known about either the dysfunctional brain activity that produces OCD symptoms or about the alteration of brain activity that underlies the reduction of OCD symptoms. Establishment of a rodent model of this disorder would facilitate development of new therapeutic strategies which are more effective and quicker acting than current medications.

Courses Taught

  • Introduction to Brain & Behavior – Psych/Neuro 170
  • Drugs, Brain and Behavior - Scientific Perspective – CORE 156S
  • Introduction to Psychology – Psych 150
  • Brain, Physiology, and Behavior – Psych/Neuro 373
  • Psychopharmacology – Psych/Neuro 377

Student Co-authored Poster Presentations

Hyde AL, Mulder HS, Craig KM, Frank SE, Kasparson LJ, and Kreiss DS (2014) The serotonin 5-HT2 antagonist mianserin, but not the serotonin 5-HT2 agonist mCPP (meta-chlorophenyl-piperazine), shows predictive validity in the behavioral rat model of Obsessive Compulsive Disorder induced via neonatal exposure to clomipramine. Society for Neurosciences Convention, Washington, D.C.
ABSTRACT

Kreiss DS, Frank SE, Craig KM, Mulder HS, Hyde AL, and Laiks LS (2014) Neonatal exposure to clomipramine is a behavioral rat model of Obsessive Compulsive Disorder offering face validity as well as predictive validity for the GABA agonist diazepam, the serotonin uptake inhibitor fluoxetine, and the norepinephrine uptake inhibitor desipramine. Society for Neurosciences Convention, Washington, D.C.
ABSTRACT

Hyde AL, Kasparson LJ, Laiks LS, Craig KM, Frank SE, Mulder HS, Kreiss DS (2014) “Neonatal exposure to clomipramine is a behavioral rat model of Obsessive Compulsive Disorder offering not only face validity, but also predictive validity for the GABA agonist diazepam, the norepinephrine uptake inhibitor desipramine, the serotonin uptake inhibitor fluoxetine, and the serotonin 5HT2 antagonist mianserin”. Faculty for Undergraduate Neuroscience Conference, Washington, D.C.
ABSTRACT

Josephine Belluardo, Charlotte Bavley, Kathleen Trychta, Ali Pesch, and Deborah Kreiss (2013) "Comparison of two novel animal models of Obsessive Compulsive Disorder: Alteration of hole-poke and marble burying behaviors induced by either acute mCPP or neonatal clomipramine exposure" . Society for Neurosciences, San Diego, CA.
ABSTRACTPOSTER

Charlotte Bavley, Josephine Belluardo, Emily Rettstatt, Kathleen Trychta and Deborah Kreiss (2013) "Neonatal exposure to clomipramine is a model of Obsessive Compulsive Disorder with unique face and predictive validity". Society for Neurosciences, San Diego, CA.
ABSTRACTPOSTER

Emily Rettstatt, Kathleen Trychta, Lauren Kasparson, Michelle Krelko, Lillian Laiks, Jenny Panger, Ashley Walsh, and Deborah Kreiss (2013) "Elevated Plus Maze behavior of rats neonatally exposed to clomipramine is dramatically altered by prior environmental experience". Society for Neurosciences, San Diego, CA.
ABSTRACTPOSTER

Lauren Kasparson, Alexander Hyde, Lillian Laiks, Quinnel Simmons and Deborah Kreiss (2013) "Evaluation of a potential animal model of Obsessive Compulsive Disorder: Effects of mCPP upon exploratory and checking behaviors". Faculty for Undergraduate Neuroscience, San Diego, CA.
ABSTRACTPOSTER

Lillian Laiks, Dominika Burek, Sierra Grzybowski, Lauren Kasparson, Michelle Krelko, Jennifer Panger, and Deborah Kreiss (2012) "The effects of serotonin uptake inhibitors on the behavior of rats neonatally treated with clomipramine: An animal model of Obsessive Compulsive Disorder?" Upstate NY Undergraduate Research Conference, Schnectady, NY.
ABSTRACT

Publications

Kreiss DS, *Coffman CF, *Fiacco NR, *Granger JC, *Helton BM, *Jackson JC, *Kim LV, *Mistry RS, *Mizer TM, *Palmer LV, *Vacca JA, *Winkler SS, and *Zimmer BA (2013) Ritualistic Chewing Behavior induced by mCPP in the rat is an animal model of Obsessive Compulsive Disorder. Pharmacology, Biochemistry and Behavior 104:119–124
* denotes student authors

Allers KA, Bergstrom DA, Ghazi LJ, Kreiss DS, and Walters JR (2005). Do systemically administered glutamate antagonists affect subthalamic nucleus activity? Relevance to pharmacotherapy of Parkinson's disease. In The Basal Ganglia VIII. JP Bolam, CA Ingham, and PJ Magill (Eds) Kluwer Academic/Plenum Publishers, New York

Allers KA, Bergstrom DA, Ghazi LJ, Kreiss DS, and Walters JR (2005). MK801 and amantadine exert different effects on subthalamic neuronal activity in a rodent model of Parkinson’s disease. Experimental Neurology 191: 104-118

Allers KA, Kreiss DS, and Walters JR (2002). Neuronal Firing Patterns in the Subthalamic Nucleus: Effects of dopamine receptor stimulation on multisecond oscillations. In The Basal Ganglia VI. AM Graybiel, MR DeLong, ST Kitai (Eds) Kluwer Academic/Plenum Publishers, New York pp. 245-254

Allers KA, Kreiss DS, and Walters JR (2000). Multisecond oscillations in the subthalamic nucleus: Effects of apomorphine and dopamine cell lesion. Synapse 38:38-50

Kreiss DS, Mastropietro CW, Rawji SS, and Walters JR (1997) The response of subthalamic nucleus neurons to dopamine receptor stimulation in a rodent model of Parkinson’s disease. Journal of Neuroscience. 17:6807-6819

Kreiss DS and Lucki I. (1997) Chronic administration of the 5-HT1A receptor agonist 8-OH-DPAT differentially desensitizes 5-HT1A autoreceptors of the dorsal and median raphe nuclei. Synapse. 25:107-116

Kreiss DS, Anderson LA, and Walters JR. (1996) Apomorphine and dopamine D1 receptor agonists increase the firing rates of subthalamic nucleus neurons. Neuroscience. 72:863-876

Kreiss DS, Bergstrom DA, Gonzalez AM, Huang KX, Sibley DR, and Walters JR. (1995) Dopamine receptor agonist potencies for inhibition of cell firing correlate with dopamine D3 receptor binding affinities. European Journal of Pharmacology. 277:209-214

Kreiss DS and Lucki I. (1995) Effects of acute and repeated administration of antidepressant drugs on extracellular levels of 5-hydroxytryptamine measured in vivo. Journal of Pharmacology and Experimental Therapeutics. 274:866-876

Kirby LG, Kreiss DS, Singh A, and Lucki I. (1995) The effect of 5,7-dihydroxytryptamine lesions on basal and fenfluramine-induced serotonin release in striatum. Synapse. 20:99-105

Kreiss DS and Lucki I. (1994) Differential regulation of serotonin (5-HT) release in the striatum and hippocampus by 5-HT1A autoreceptors of the dorsal and median raphe nuclei. Journal of Pharmacology and Experimental Therapeutics. 269:1268-1279

Kreiss DS and Lucki I. (1994) Discriminative stimulus properties of the serotonin uptake inhibitor sertraline. Experimental and Clinical Psychopharmacology. 2:1-12

Lucki I, Singh A, and Kreiss DS. (1994) Antidepressant-like behavioral effects of serotonin receptor agonists. Neuroscience and Biobehavioral Review. 18:85-95

Kreiss DS, Wieland S, and Lucki I. (1993) The presence of a serotonin uptake inhibitor alters pharmacological manipulations of serotonin release. Neuroscience. 52:295-301

Kreiss DS and Lucki I. (1992) Desensitization of 5-HT1A autoreceptors by chronic administration of 8-OH-DPAT as assessed with in vivo microdialysis. Neuropharmacology. 31:1073-1075